Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors (Neuron)

Chronic stress is a major risk factor for depression. Cerniauskas et al. identify a lateral habenula subcircuit involved in chronic stress-induced increased passive coping and reduced motivated behaviors. Single-cell transcriptomics reveal potential gene targets associated with this specific behavioral phenotype.