Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A (Beilstein Journal of Organic Chemistry)

Abstract The construction of the biologically interesting chromone skeleton was realized by PhIO-mediated dehydrogenation of chromanones under mild conditions. Interestingly, this method also found application in the synthesis of the naturally occurring frutinone A. Beilstein J. Org. Chem. 2019, 15, 2958–2965. doi:10.3762/bjoc.15.291