Anchors Away: Glia-Neuron Adhesion Regulates Myelin Targeting and Growth (Developmental Cell)

Myelination in the CNS requires oligodendrocytes to first select correct axonal targets and then extend their membranes around and along these axons. In this issue of Developmental Cell, Klingseisen et al. (2019) find that the adhesion protein Neurofascin is required in oligodendrocytes for both target selection and myelin growth.