Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration (Cell Stem Cell)

Xiang and colleagues report a method for generating human medial ganglionic eminence (MGE)-like organoids (hMGEOs) and cortical-like organoids (hCOs), which resemble the developing human MGE and cortex, respectively. By fusing hMGEOs and hCOs, they establish a 3D model to investigate human interneuron migration.