In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors (Cell Metabolism)

Salamanca-Cardona et al. show that glutamine is a primary carbon source for the biosynthesis of the oncometabolite 2-hydroxyglutarate in mutant IDH tumors. They develop a novel hyperpolarized MRI method using glutamine as a probe to detect 2-hydroxyglutarate formation in vivo in real time, non-invasively, and with high specificity.