Higher-Order Kidney Organogenesis from Pluripotent Stem Cells (Cell Stem Cell)

Taguchi and Nishinakamura define signals that specifically induce ureteric bud and nephron progenitor lineages from PSCs. Co-culturing these progenitors can generate organoids that mimic organotypic architecture of the embryonic kidney with nephrons interconnected by branched epithelium, showing that higher-order organogenesis can be recapitulated in PSC-derived organoids.