ORP-Mediated ER Contact with Endocytic Sites Facilitates Actin Polymerization (Developmental Cell)

Clathrin-mediated endocytosis from the plasma membrane is thought to mostly rely on the assembly of a coat built from cytosolic proteins. In contrast, Encinar et al. demonstrate that the ER contacts endocytic sites and plays a role in facilitating membrane invagination for endocytosis.