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RSS FeedsThe ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis (Current Biology)

 
 

8 april 2018 18:00:05

 
The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis (Current Biology)
 


Zhao et al. demonstrate that the ER-localized proteins VAPA and VAPB participate in ER/isolation membrane contact formation for autophagosome biogenesis. VAPA/B interact with FIP200 and ULK1 through their FFAT motifs to facilitate assembly of the autophagy initiation complex on the ER.


 
186 viewsCategory: Biology
 
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