Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling (Developmental Cell)

Traditionally, the ryanodine receptor has been associated with mediating the release of calcium from intracellular stores to trigger muscle contraction. Klatt Shaw et al. demonstrate levels of ryanodine receptor activity tune a cell`s response to Hedgehog signaling, affecting Hedgehog-dependent gene expression and tissue patterning.