Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile (Cell Reports)

Kim et al. compared mitochondrial features in aging human fibroblasts and directly induced neurons (iNs). They find that only iNs display severe signs of mitochondrial aging defects and show that the metabolic shift during fibroblast-to-neuron conversion renders iNs particularly vulnerable to mitochondrial aging.