Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis (Developmental Cell)

Poudel et al. show that endophilin A3 (EndoA3) modulates proliferation and migration of colorectal cancer cells using two distinct pathways, i.e., EndoA3 facilitates cell proliferation by enhancing endocytosis, and it promotes migration by activating TIAM1 and Rac1. Modulation of the two pathways tunes tumor progression in vivo.