Regulated Crossing-Over Requires Inactivation of Yen1/GEN1 Resolvase during Meiotic Prophase I (Developmental Cell)

In many organisms, the faithful disjunction of maternal and paternal centromeres during meiosis I requires homologous recombination and crossing-over. Here, Arter et al. show that phosphorylation-mediated inactivation of the Yen1/GEN1 resolvase, during prophase I, avoids the precocious resolution of recombination intermediates to enable controlled crossover formation throughout the genome.