Cell Biology
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19 june 2018 01:00:33 |
| AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells (Cell Stem Cell) |
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Tweet Human acute myeloid leukemia stem cells (LSCs) depend on FIS1-mediated mitophagy for self-renewal and survival. AMPK is constitutively active in human LSCs, is upstream of FIS1, and acts to stimulate mitophagy. Disruption of AMPK signaling or FIS1 activity results in eradication of LSCs. |
| 177 viewsCategory: Cell Biology |
 Instructions for Assembling the Early Mammalian Embryo (Developmental Cell)Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency (Cell Stem Cell) 
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