Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency (Cell Stem Cell)

Rapid reprogramming of epiblast stem cells (EpiSCs) to induced pluripotent stem cells (iPSCs) allows a detailed analysis of epigenetic remodeling induced by transcription factors. The orphan nuclear receptor Esrrb plays a pioneering role in establishing a permissive chromatin environment for the recruitment of core pluripotency factors Oct4, Sox2, and Nanog.