Virus-Induced Changes in mRNA Secondary Structure Uncover cis-Regulatory Elements that Directly Control Gene Expression (Molecular Cell)

Gene regulation via RNA structure constitutes an important component of post-transcriptional regulation. By systematically mapping dynamic changes in mRNA structure, Mizrahi et al. uncover that translation unwinds secondary structure inside cells. They further uncover structural elements in 3´ UTRs that regulate mRNA stability and elements within coding sequences that control translation.