Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing (Cell Reports)

Joost et al. elucidate how skin stem cells from different niches respond upon injury. Single-cell transcriptomics revealed that Lgr5 and Lgr6 progeny molecularly converge during wound healing. Instant cell adaptations of Lgr5 cells within their original niche permit interactions with the wound environment, an ability Lgr6 cells already possess before wounding.