Salt-Responsive Metabolite, ?-Hydroxybutyrate, Attenuates Hypertension (Cell Reports)

Chakraborty et al. report a link between dietary salt, a ketone, and experimental hypertension. Intake of a high salt diet lowers the ketone body beta-hydroxybutyrate (?OHB), produced by the liver, which functions to prevent Nlrp3-mediated kidney inflammation. Rescuing ?OHB by nutritional supplementation of its precursor attenuates hypertension.