Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis (Cell Metabolism)

HDL removes tissue cholesterol and recirculates to the plasma. Huang et al. generated a photoactivatable HDL tracking tool that they applied to psoriasis, which has been clinically linked to cardiovascular comorbidity. They find that Th17 autoimmunity promotes collagen deposition in skin and arteries, thus entrapping HDL and LDL to drive cardiovascular risk.