The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation (Structure)

Ostertag et al. solved the co-crystal structure of SPOP and Pdx1 and studied the effects of Pdx1 phosphorylation on SPOP binding strength. The interaction of the proteins leads to Pdx1 degradation and is considered a key regulatory mechanism for insulin homeostasis.