Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter (Structure)

Kusakizako et al. determined the crystal structures of VcmN, an H+-coupled MATE transporter from Vibrio cholerae. A structural comparison of distinct conformations associated with different pH conditions and the D35N mutation in TM1 reveals the common step in the transport cycle shared among prokaryotic H+-coupled MATE transporters.