Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68) (Current Biology)

Wei et al. show that the proton-sensing receptor OGR1/GPR68 is a coincidence detector of extracellular pH and substrate stiffness via changes in cell stretch. Changes in matrix stiffness and pH occur physiologically and pathologically. OGR1 is ideally positioned to sense and respond to changes in both, thus influencing cell, tissue, and organ fate.