Oncology
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24 november 2018 07:00:13 |
| KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance (Cancer Cell) |
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Tweet Hinohara et al. demonstrate that histone demethylases KDM5A and KDM5B are key regulators of phenotypic heterogeneity in estrogen receptor (ER)-positive breast cancer. Inhibition of KDM5 activity increases sensitivity to endocrine therapy by modulating ER signaling. |
| 159 viewsCategory: Cell Biology, Oncology |
 Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer (Cancer Cell)Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia (Cancer Cell) 
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