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RSS FeedsEnhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia (Cancer Cell)

 
 

30 november 2018 23:00:03

 
Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia (Cancer Cell)
 




Analyzing integrative enhancer profiles and transcription factor dependencies, Ott et al. construct enhancer-based core regulatory circuits of chronic lymphocytic leukemia (CLL) and reveal a dominant and essential role for PAX5. BET inhibition disrupts CLL super enhancer networks and suppresses CLL growth.


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136 viewsCategory: Cell Biology, Oncology
 
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