Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic ? Cells (Cell Chemical Biology)

Lack of cell-type selectivity prevents translational use of ?-cell replication-promoting compounds. Based upon the high zinc content of ? cells, Horton et al. explored functionalizing a ?-cell-replicating molecule with a zinc-chelating moiety for targeted drug delivery. These studies validate a transferrable technology for ?-cell-targeted drug delivery.