Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome (Cell Reports)

In a mouse model of Dravet syndrome (DS) resulting from voltage-gated sodium channel deficiency, Ritter-Makinson et al. find that inhibitory neurons of the reticular thalamic nucleus are paradoxically hyperexcitable due to compensatory reductions in a potassium SK current. Boosting this SK current treats non-convulsive seizures in DS mice.