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RSS FeedsGDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans (Cell Metabolism)

 
 

13 january 2019 04:01:39

 
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans (Cell Metabolism)
 




Patel et al. show that whereas short-term overfeeding or fasting does not change GDF15 levels substantially, prolonged high-fat feeding and lysine-deficient diets activate the integrated stress response and increase GDF15 levels. GDF15 administration triggers conditioned taste aversion in mice, suggesting that GDF15 might induce an aversive response to nutritional stress.


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105 viewsCategory: Cell Biology
 
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