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RSS FeedsRestricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells (Cell Reports)

 
 

16 january 2019 04:00:05

 
Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells (Cell Reports)
 


Tomaru et al. show that aberrant expression of self-peptides generated by thymoproteasomes, which are expressed exclusively in the thymic cortex, affects CD8+ T cell homeostasis. Restricted expression of thymoproteasomes is crucial for thymic selection, maintenance of the peripheral naive pool of CD8+ T cells, and avoiding autoimmune responses.


 
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