Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation (Cancer Cell)

Hepatocellular carcinomas (HCCs) often retain the wild-type p53. Kim et al. find that p53 is important for the growth of HCC cells and that p53-regulated PUMA reduces mitochondrial pyruvate uptake and increases glycolysis in HCC, suggesting caution when designing cancer treatment strategies that activate p53.