A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK (Cancer Cell)

Using a bioinformatics analysis, Feng et al. identify FAK as a vulnerability of uveal melanoma (UM) with oncogenic G?q and show that inhibition of FAK reduces UM growth. G?q activates FAK via the non-canonical TRIO-RhoA pathway, and FAK in turn regulates YAP, known to be critical for UM, by phosphorylating MOB1.