E93 Integrates Neuroblast Intrinsic State with Developmental Time to Terminate MB Neurogenesis via Autophagy (Current Biology)

Pahl et al. find that E93 is required to precisely time the end of neurogenesis during development. E93 is temporally expressed in MB neuroblasts and is regulated by extrinsic hormone cues and by neuroblast intrinsic temporal factors. E93 forms a temporal cassette with Imp and Syp, which links early developmental neurogenesis with termination.