PINK1 Inhibits Local Protein Synthesis to Limit Transmission of Deleterious Mitochondrial DNA Mutations (Molecular Cell)

Mitochondrial DNA accumulates mutations at high frequency in the body, yet few deleterious mutations are transmitted to the offspring, suggesting that they are eliminated from reproductive tissues. Zhang et al. report that in Drosophila ovaries this elimination relies on the protein PINK1, which marks defective mitochondria and limits their DNA`s proliferation.