Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq (Molecular Cell)

Guo et al. report the cell fate continuum during induced pluripotent stem cell (iPSC) reprogramming at single-cell resolution. By developing SOT as a new analytic tool, they identify several previously unknown bifurcation points along the reprogramming path and propose a generic bifurcation model for cell fate decisions.