Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence (Molecular Cell)

Epigenetic dysregulation is a hallmark of senescence and aging. In this article, Sen et al. have identified the histone acetyltransferase p300 as a key protein regulating senescence from a high-throughput screen. p300 induces formation of new super enhancers that drive senescence-related gene expression. p300 is an attractive candidate for anti-aging therapy.