Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination (Molecular Cell)

Kamieniarz-Gdula and colleagues demonstrate that vertebrate PCF11 plays selective roles in regulating transcriptional termination and RNA 3´ end processing. It is important for efficient expression of closely spaced genes but in some cases promotes premature termination and gene downregulation. Especially PCF11 transcript levels are kept low by this attenuation mechanism.