MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis (Molecular Cell)

Leimbacher et al. reveal that two DNA damage-response mediator proteins, MDC1 and TOPBP1, form a complex required for maintaining chromosome stability when DNA double-strand breaks occur during mitosis, possibly by tethering broken chromosomes together until DNA-repair pathways are reactivated in the following G1 phase.