Gene-Specific H1 Eviction through a Transcriptional Activator->p300->NAP1->H1 Pathway (Molecular Cell)

Shimada et al. report that H1 eviction during transcription entails NAP1 recruitment by activator-bound p300, leading to histone acetylation and simultaneous removal of H1 and H2A-H2B. A B cell maturation model further demonstrates that H1 eviction is seeded by activator-p300 and NAP1 and continues in a wave to the nearest CTCF binding sites.