X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation (Structure)

Jackson et al. determine the structure of human SQOR, a monotopic mitochondrial membrane protein that regulates physiological levels of the gasotransmitter hydrogen sulfide. The structure uncovers the basis for the enzyme`s ability to catalyze sulfane sulfur transfer reactions with structurally diverse acceptors and opens the door for structure-based drug design.