Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity (Cell Chemical Biology)

Cyclin-dependent kinase 14 (CDK14) is an understudied kinase that lacks functional annotation. The authors develop and characterize a covalent CDK14 inhibitor, FMF-04-159-2, and use it to interrogate the role of CDK14 in the cell cycle and phospho-signaling.