Translocation of a Cell Surface Spliceosomal Complex Induces Alternative Splicing Events and Lymphoma Cell Necrosis (Cell Chemical Biology)

Tonapi et al. identified a surface spliceosomal complex with hnRNPU as a core component on the surface of Burkitt`s lymphoma cells using ssDNA aptamer C10.36. The aptamer binds this complex selectively, internalizes into the targeted cells, leading to splicing aberrations and ultimately to cell death via necrosis.