Investigation of Penicillin Binding Protein (PBP)-like Peptide Cyclase and Hydrolase in Surugamide Non-ribosomal Peptide Biosynthesis (Cell Chemical Biology)

Zhou et al. reported a penicillin binding protein (PBP)-like thioesterase catalyzing peptide chain termination in surugamide non-ribosomal peptide (NRP) biosynthesis. The family of enzymes is widely distributed in NRP biosynthetic pathways in bacteria, either as standalones or C-terminal domains of multidomain NRPSs, suggesting a general mechanism in Nature.