Biophysical Characterization of a Nanodisc with and without BAX: An Integrative Study Using Molecular Dynamics Simulations and Cryo-EM (Structure)

López et al. analyze the structure and dynamics of lipid nanodiscs, both empty and in complex with pro-apoptotic BAX protein. Information from the computational-derived structures prompted changes in image-processing strategy, which led to quality improvements in cryo-EM reconstructions. Together, these findings provide novel insights on the activity of BAX.