PAX3 Confers Functional Heterogeneity in Skeletal Muscle Stem Cell Responses to Environmental Stress (Cell Stem Cell)

Der Vartanian and colleagues identify a functional heterogeneity of skeletal muscle stem cell response to environmental stress. While PAX3-negative muscle stem cells display impaired survival, aberrant activation, and sporadic fusion to myofibers upon TCDD exposure, PAX3-positive muscle stem cells are protected against the pollutant through an mTORC1-dependent G(alert) response.