Upregulation of E93 Gene Expression Acts as the Trigger for Metamorphosis Independently of the Threshold Size in the Beetle Tribolium castaneum (Cell Reports)

In the present study, Chafino et al. identify the upregulation of E93 expression as the trigger for metamorphosis in the holometabolous insect Tribolium castaneum. Depletion of E93 prevents pupa formation, whereas precocious E93 upregulation, by either JH depletion or nutrition restriction, induces premature onset of metamorphosis.