Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing (Cell Reports)

Ganem et al. report that the C. elegans enzymatic-inactive ADR-1 regulates A-to-I RNA editing by directing editing by ADR-2, mainly at the L4 developmental stage. Changes in RNA editing levels severely affect normal development by changing RNA levels, but not protein levels.