Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFR? in Adult Brain (Cell Reports)

?ang et al. show that oligodendrocyte progenitor cells (OPCs) are repopulated from pericyte and/or mesenchymal cell population (PC/MC) and from OPCs that escape Pdgfra inactivation. PC/MC-derived OPCs can differentiate into MBP-expressing mature oligodendrocytes. Our findings reveal a mechanism of homeostatic control of adult OPCs engaging dual cellular sources of adult OPC formation.