Development of a Cx46 Targeting Strategy for Cancer Stem Cells (Cell Reports)

Cx46 was previously shown to be essential for glioblastoma cancer stem cell maintenance. Here, Mulkearns-Hubert et al. show that cancer stem cells depend on Cx46-mediated cell-cell communication and identify a Cx46 inhibitor, clofazimine. Clofazimine preferentially inhibits Cx46-mediated communication and targets cancer stem cells to decrease tumor growth.