Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction (Immunity)

Regulatory T (Treg) cells are important for preventing autoimmunity and maintaining tissue homeostasis. Schmidleithner et al. report a hydroxyprostaglandin dehydrogenase (HPGD)-mediated tissue- and context-dependent suppressor mechanism used by Treg cells to maintain adipose tissue homeostasis through the metabolism of PGE2 into the PPAR? ligand 15-keto-PGE2, which is conserved in human and mouse.