A SNP in a Steroidogenic Enzyme Is Associated with Phenotypic Sex in Seriola Fishes (Current Biology)

Koyama et al. report that a SNP in the steroidogenic Hsd17b1 gene, which is involved in estrogen production, strictly correlates with phenotypic sex in Seriola fishes. This SNP causes the G144E/K mutation, which attenuates E1-to-E2 conversion in males. The results strongly support a long-standing hypothesis on steroid-induced sex determination.