Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids (Cell Stem Cell)

Artegiani et al. show that BAP1 mutation in human liver organoids coincides with loss of multiple epithelial characteristics through impairment of chromatin accessibility and gene expression, and this is critical for the acquisition of malignant features in a human model of cholangiocarcinoma.