Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs (Molecular Cell)

Clijsters et al. elucidate how cyclin F controls a major transcriptional cell-cycle engine. The authors show that activating E2Fs are targeted for proteasomal degradation in late S and G2, resetting the transcriptional program and preventing unscheduled item into the next S phase. Long-term stabilization of activator E2Fs impairs cell fitness.